A slowing of the frequencies of the ECoG content is
present in this case. A balanced change in the frequency composition of ECoG
(i.e. HGH FRAG 176-191
in high frequencies and increase in low frequencies) occurs at moderate levels
of hypoxemia and are in keeping with known intracellular changes in
excitability in response to an O2 sensing mechanism ipamorelin.
The effect of the vascular response to hypoxemia on the global amount of
cortical electrical activity suggests important clinical consequences in
patients with impaired cerebral circulation (OSA patients) or during adaptation
to high altitude.
Our data, in anesthetized rats, thus, indicate that relative hypoperfusion
associated with ipamorelin adds an
adverse effect based on ECoG. Total power of the signal, which represents
global electrical activity, is significantly reduced. This is not the case when
CBF response to hypoxemia is preserved (in the same animals).
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